MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3B is one of the light chain subunits and can associate with either MAP1A or MAP1B. It is a Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). LC3B plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
Titration of the LC3B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 89-122 from the human protein was used as the immunogen for this LC3B antibody.
Aliquot the LC3B antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
