The protein encoded by the intronless THBD gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [RefSeq]

Optimal dilution of the CD141 antibody should be determined by the researcher.

A synthetic peptide specific to human Thrombomodulin / CD141 was used as the immunogen for the CD141 antibody.

Store the CD141 antibody at -20oC.