Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. [UniProt]

The stated application concentrations are suggested starting points.Titration of the CD14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 25-148 was used as immunogen for this CD14 antibody.

Store the CD14 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).