This gene, a Kirsten ras oncogene homolog from themammalian ras gene family, encodes a protein that is a member ofthe small GTPase superfamily. A single amino acid substitution isresponsible for an activating mutation. The transforming proteinthat results is implicated in various malignancies, including lungadenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreasand colorectal carcinoma. Alternative splicing leads to variantsencoding two isoforms that differ in the C-terminal region.
Titration of the KRAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 146-174 from the human protein was used as the immunogen for this KRAS antibody.
Aliquot the KRAS antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
