The PDGFRA gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [RefSeq]

Optimal dilution of the PDGFRA antibody should be determined by the researcher.

A synthetic peptide specific to human PDGFR alpha / PDGFRA was used as the immunogen for the PDGFRA antibody.

Store the PDGFRA antibody at -20oC.