The CYP19A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [RefSeq]

Optimal dilution of the Aromatase antibody should be determined by the researcher.

A synthetic peptide specific to human Aromatase / CYP19A1 was used as the immunogen for the Aromatase antibody.

Store the Aromatase antibody at -20oC.