Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. The ITGB4 gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. [RefSeq]

Optimal dilution of the CD104 antibody should be determined by the researcher.

A synthetic peptide specific to human Integrin beta 4 / ITGB4 was used as the immunogen for the CD104 antibody.

Store the CD104 antibody at -20oC.