The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [RefSeq]

Optimal dilution of the Ku70 antibody should be determined by the researcher.

A synthetic peptide specific to human Ku70 / XRCC6 was used as the immunogen for the Ku70 antibody.

Store the Ku70 antibody at -20oC.