Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [UniProt]

Optimal dilution of the hydroxyl-Histone H2A antibody (Tyr39) should be determined by the researcher.

A synthetic peptide specific to human Histone H2A (surrounding hydroxylated tyrosine 39) was used as the immunogen for the hydroxyl-Histone H2A antibody.

Store the hydroxyl-Histone H2A antibody (Tyr39) at -20oC.