Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. [UniProt]

The stated application concentrations are suggested starting points.Titration of the TLE1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 175-338 from the human protein was used as the immunogen for the TLE1 antibody.

Store the TLE1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).