Canalicular multispecific organic anion transporter 2 is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Thisprotein is a member of the MRP subfamily which is involved inmulti-drug resistance. The specific function of this protein hasnot yet been determined; however, this protein may play a role inthe transport of biliary and intestinal excretion of organicanions. Alternatively spliced variants which encode differentprotein isoforms have been described; however, not all variantshave been fully characterized.
Titration of the ABCC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 899-925 from the human protein was used as the immunogen for this ABCC3 antibody.
Aliquot the ABCC3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
