This gene encodes proteins related to the first discoveredblood group system, ABO. Which allele is present in an individualdetermines the blood group. The "O" blood group is caused by adeletion of guanine-258 near the N-terminus of the protein whichresults in a frameshift and translation of an almost entirelydifferent protein. Individuals with the A, B, and AB allelesexpress glycosyltransferase activities that convert the H antigeninto the A or B antigen. Other minor alleles have been found forthis gene.
Titration of the ABO antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 41-68 from the human protein was used as the immunogen for this ABO antibody.
Aliquot the ABO antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
