Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. [UniProt]

Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 794-823 from the human protein was used as the immunogen for this ADAM17 antibody.

Aliquot the ADAM17 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.