Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. [UniProt]

Titration of the AIM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1-50 from the human protein was used as the immunogen for this AIM2 antibody.

Aliquot the AIM2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.