Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia.
Titration of the ALDOA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 303-331 from the human protein was used as the immunogen for this ALDOA antibody.
Aliquot the ALDOA antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
