Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

Optimal dilution of the Alpha Catenin antibody to be determined by the researcher.

A human fusion protein was used as the immunogen for the Alpha Catenin antibody.

Store the Alpha Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).