Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases.Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis.

Provided assay concentrations are suggestions only, Als2Cr2 antibody titration may be required for optimal results.This antibody will detect the 418 (ILPIP alpha) and 280 (ILPIP beta) amino acid isoforms.

A recombinant protein fragment from the interior region of human Als2Cr2 was used as the immunogen for this antibody.

Aliquot the Als2Cr2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.

Amyotrophic lateral sclerosis 2 chromosome region candidate 2, ILPIP, STRADB