AMACR, also known as p504S is an enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands.

Optimal dilution of the AMACR antibody should be determined by the researcher.

A recombinant human protein was used as the immunogen for the AMACR antibody.

Store the AMACR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).