PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5"-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.

Titration of the AMPK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 474-502 from human PRKAA1 was used as the immunogen for this AMPK antibody.

Aliquot the AMPK antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.