The APP gene encodes Amyloid beta, a cell surface receptor andtransmembrane precursor protein that is cleaved by secretases toform a number of peptides. Some of these peptides are secreted andcan bind to the acetyltransferase complex APBB1/TIP60 to promotetranscriptional activation, while others form the protein basis ofthe amyloid plaques found in the brains of patients with Alzheimerdisease. Mutations in this gene have been implicated in autosomaldominant Alzheimer disease and cerebroarterial amyloidosis(cerebral amyloid angiopathy). Multiple transcript variantsencoding several different isoforms have been found for this gene.
Titration of the anti-APP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 333-362 from the human protein was used as the immunogen for this anti-APP antibody.
Aliquot the anti-APP antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
