This gene encodes a member of the epidermal growth factorsuperfamily. The encoded protein is synthesized as a largeprecursor molecule that is proteolytically cleaved to generate the53-amino acid epidermal growth factor peptide. This protein acts apotent mitogenic factor that plays an important role in the growth,proliferation and differentiation of numerous cell types. Thisprotein acts by binding the high affinity cell surface receptor,epidermal growth factor receptor. Defects in this gene are thecause of hypomagnesemia type 4. Dysregulation of this gene has beenassociated with the growth and progression of certain cancers.Alternate splicing results in multiple transcript variants.

Titration of the anti-EGF antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 940-967 from the human protein was used as the immunogen for this anti-EGF antibody.

Aliquot the anti-EGF antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.