This gene encodes a member of the forkhead/winged-helix(FOX) family of transcription factors. It is expressed in fetal andadult brain as well as in several other organs such as the lung andgut. The protein product contains a FOX DNA-binding domain and alarge polyglutamine tract and is an evolutionarily conservedtranscription factor, which may bind directly to approximately 300to 400 gene promoters in the human genome to regulate theexpression of a variety of genes. This gene is required for properdevelopment of speech and language regions of the brain duringembryogenesis, and may be involved in a variety of biologicalpathways and cascades that may ultimately influence languagedevelopment. Mutations in this gene cause speech-language disorder1 (SPCH1), also known as autosomal dominant speech and languagedisorder with orofacial dyspraxia. Multiple alternative transcriptsencoding different isoforms have been identified in this gene.

Titration of the anti-FOXP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 657-684 from the human protein was used as the immunogen for this anti-FOXP2 antibody.

Aliquot the anti-FOXP2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.