HER2/ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An interaction with PRKCABP has been suggested.Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.
Titration of the anti-HER2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 1227-1255 from the human protein was used as the immunogen for this anti-HER2 antibody.
Aliquot the anti-HER2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
