Anaphase-promoting complex subunit 11, together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of "Lys-11"-linked polyubiquitin chains and, to a lower extent, the formation of "Lys-48"- and "Lys-63"-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Titration of the APC11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 56-94 from the human protein was used as the immunogen for the APC11 antibody.

Aliquot the APC11 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.