This gene encodes a member of the degenerin/epithelialsodium channel (DEG/ENaC) superfamily. The members of this familyare amiloride-sensitive sodium channels that contain intracellularN and C termini, two hydrophobic transmembrane regions, and a largeextracellular loop, which has many cysteine residues with conservedspacing. The member encoded by this gene is an acid sensor and mayplay an important role in the detection of lasting pH changes. Inaddition, a heteromeric association between this member and ACCN1/ASIC2has been observed as proton-gated channels sensitive to gadolinium.Alternative splicing of this gene generates three transcriptvariants encoding distinct isoforms.

Titration of the ASIC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 55-83 from the human protein was used as the immunogen for this ASIC3 antibody.

Aliquot the ASIC3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.