This gene belongs to the superfamily of acid-sensing ionchannels, which are proton-gated, amiloride-sensitive sodiumchannels. These channels have been implicated in synaptictransmission, pain perception as well as mechanoperception. Thisgene is predominantly expressed in the pituitary gland, and wasconsidered a candidate for paroxysmal dystonic choreoathetosis(PDC), a movement disorder, however, no correlation was foundbetween mutations in this gene and PDC. Alternative splicing atthis locus results in two transcript variants encoding differentisoforms.

Titration of the ASIC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 23-52 from the human protein was used as the immunogen for this ASIC4 antibody.

Aliquot the ASIC4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.