Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

Titration of the AURKC antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of the C-terminal region of the human protein was used as immunogen for this AURKC antibody.

Aliquot the AURKC antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.