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当前位置: 首页 > 产品中心 > monoclonal_antibody > NSJ Bio/AXIN2 Antibody / Axis inhibition protein 2 (F49172)/0.4 ml/F49172-0.4ML
商品详细NSJ Bio/AXIN2 Antibody / Axis inhibition protein 2 (F49172)/0.4 ml/F49172-0.4ML
NSJ Bio/AXIN2 Antibody / Axis inhibition protein 2 (F49172)/0.4 ml/F49172-0.4ML
NSJ Bio/AXIN2 Antibody / Axis inhibition protein 2 (F49172)/0.4 ml/F49172-0.4ML
商品编号: F49172-0.4ML
品牌: NSJBioreagents
市场价: ¥7580.00
美元价: 6064.00
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description

The Axin-related protein, Axin2, presumably plays animportant role in the regulation of the stability of beta-cateninin the Wnt signaling pathway, like its rodent homologs, mouseconductin/rat axil. In mouse, conductin organizes a multiproteincomplex of APC (adenomatous polyposis of the colon), beta-catenin,glycogen synthase kinase 3-beta, and conductin, which leads to thedegradation of beta-catenin. Apparently, the deregulation ofbeta-catenin is an important event in the genesis of a number ofmalignancies. The AXIN2 gene has been mapped to 17q23-q24, a regionthat shows frequent loss of heterozygosity in breast cancer,neuroblastoma, and other tumors. Mutations in this gene have beenassociated with colorectal cancer with defective mismatch repair.

Application Notes

Titration of the AXIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.

Storage

Aliquot the AXIN2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.

品牌介绍
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