Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer"s disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the "Down critical region" of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
Titration of the BACE2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 336-365 from the human protein was used as the immunogen for this BACE2 antibody.
Aliquot the BACE2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
