B cell-activating factor (BAFF) enhances B-cell survivalin vitro and is a regulator of the peripheral B-cell population.Overexpression of Baff in mice results in mature B-cell hyperplasiaand symptoms of systemic lupus erythematosus (SLE). Also, some SLEpatients have increased levels of BAFF in serum. Therefore, it hasbeen proposed that abnormally high levels of BAFF may contribute tothe pathogenesis of autoimmune diseases by enhancing the survivalof autoreactive B cells. The protein encoded by this gene is areceptor for BAFF and is a type III transmembrane proteincontaining a single extracellular cysteine-rich domain. It isthought that this receptor is the principal receptor required forBAFF-mediated mature B-cell survival.

Titration of the BAFF Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1-30 from the human protein was used as the immunogen for this BAFF Receptor antibody.

Aliquot the BAFF Receptor antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.