The protein encoded by this gene is a zinc fingertranscription factor and contains an N-terminal POZ domain. Thisprotein acts as a sequence-specific repressor of transcription, andhas been shown to modulate the transcription of START-dependentIL-4 responses of B cells. This protein can interact with a varietyof POZ-containing proteins that function as transcriptioncorepressors. This gene is found to be frequently translocated andhypermutated in diffuse large-cell lymphoma (DLCL), and may beinvolved in the pathogenesis of DLCL. Alternatively splicedtranscript variants encoding different protein isoforms have beenfound for this gene.

Titration of the BCL-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 676-704 from the human protein was used as the immunogen for this BCL-6 antibody.

Aliquot the BCL-6 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.