Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells.

Titration of the beta III Tubulin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 36-63 from the human protein was used as the immunogen for this beta III Tubulin antibody.

Aliquot the beta III Tubulin antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.