This gene encodes a member of the bone morphogeneticprotein (BMP) receptor family of transmembrane serine/threoninekinases. The ligands of this receptor are BMPs, which are membersof the TGF-beta superfamily. BMPs are involved in endochondral boneformation and embryogenesis. These proteins transduce their signalsthrough the formation of heteromeric complexes of 2 different typesof serine (threonine) kinase receptors: type I receptors of about50-55 kD and type II receptors of about 70-80 kD. Type II receptorsbind ligands in the absence of type I receptors, but they requiretheir respective type I receptors for signaling, whereas type Ireceptors require their respective type II receptors for ligandbinding. Mutations in this gene have been associated with primarypulmonary hypertension.

Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 134-162 from the human protein was used as the immunogen for this BMPR1B antibody.

Aliquot the BMPR1B antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.