BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. The gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people.

Titration of the BRD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1313-1342 from the human protein was used as the immunogen for this BRD4 antibody.

Aliquot the BRD4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.