CAMKK2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 appears to be involved in hippocampal activation of CREB1.
Titration of the CAMKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 52-82 from the human protein was used as the immunogen for this CAMKK2 antibody.
Aliquot the CAMKK2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
