The cannabinoid delta-9-tetrahydrocannabinol is theprincipal psychoactive ingredient of marijuana. Cannabinoid receptor 2 and cannabinoid receptor 1 (brain) (CNR1)have the characteristics of a guanine nucleotide-bindingprotein (G-protein)-coupled receptor for cannabinoids. They inhibitadenylate cyclase activity in a dose-dependent, stereoselective,and pertussis toxin-sensitive manner. These proteins have beenfound to be involved in the cannabinoid-induced CNS effects(including alterations in mood and cognition) experienced by usersof marijuana. The cannabinoid receptors are members of family 1 ofthe G-protein-coupled receptors.

Titration of the CB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 329-356 from the human protein was used as the immunogen for this CB2 antibody.

Aliquot the CB2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.