Chemokines are a group of small (approximately 8 to 14kD), mostly basic, structurally related molecules that regulatecell trafficking of various types of leukocytes throughinteractions with a subset of 7-transmembrane, G protein-coupledreceptors. Chemokines also play fundamental roles in thedevelopment, homeostasis, and function of the immune system, andthey have effects on cells of the central nervous system as well ason endothelial cells involved in angiogenesis or angiostasis.Chemokines are divided into 2 major subfamilies, CXC and CC, basedon the arrangement of the first 2 of the 4 conserved cysteineresidues; the 2 cysteines are separated by a single amino acid inCXC chemokines and are adjacent in CC chemokines. CCR10 is thereceptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactionsare involved in T cell-mediated skin inflammation (Homey et al.,2002 [PubMed 11821900]).

Titration of the CCR10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 1-30 from the human protein was used as the immunogen for this CCR10 antibody.

Aliquot the CCR10 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.