CCR8 encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. Chemokines and theirreceptors are important for the migration of various cell typesinto the inflammatory sites. This receptor protein preferentiallyexpresses in the thymus. I-309, thymus activation-regulatedcytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1beta) have been identified as ligands of this receptor. Studies ofthis receptor and its ligands suggested its role in regulation ofmonocyte chemotaxis and thymic cell apoptosis. More specifically,this receptor may contribute to the proper positioning of activatedT cells within the antigenic challenge sites and specialized areasof lymphoid tissues. CCR8 is located at the chemokine receptorgene cluster region.

Titration of the CCR8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 290-317 from the human protein was used as the immunogen for this CCR8 antibody.

Aliquot the CCR8 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.