CD133/PROM1/Prominin-1 may play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. [UniProt]

The stated application concentrations are suggested starting points. Titration of the CD133 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A human recombinant partial protein was used as the immunogen for this CD133 antibody.

Store the CD133 antibody at -20oC.