This antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1b molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. It is also expressed in interdigitating cells.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the CD1b antibody to be titered up or down for optimal performance.

Human peripheral lymphocytes were used as the immunogen for this CD1b antibody.

Store the CD1b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

hTa1 thymocyte antigen; Ly38; T6/Leu6