This gene encodes a divergent member of the CD1 family oftransmembrane glycoproteins, which are structurally related to themajor histocompatibility complex (MHC) proteins and formheterodimers with beta-2-microglobulin. The CD1 proteins mediatethe presentation of primarily lipid and glycolipid antigens of selfor microbial origin to T cells. The human genome contains five CD1family genes organized in a cluster on chromosome 1. The CD1 familymembers are thought to differ in their cellular localization andspecificity for particular lipid ligands. The protein encoded bythis gene localizes to late endosomes and lysosomes via atyrosine-based motif in the cytoplasmic tail.
Titration of the CD1d antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 177-206 from the human protein was used as the immunogen for this CD1d antibody.
Aliquot the CD1d antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
