The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is expressed by activated,but not by resting, T and B cells. TRAF2 and TRAF5 can interactwith this receptor, and mediate the signal transduction that leadsto the activation of NF-kappaB. This receptor is a positiveregulator of apoptosis, and also has been shown to limit theproliferative potential of autoreactive CD8 effector T cells andprotect the body against autoimmunity. Two alternatively splicedtranscript variants of this gene encoding distinct isoforms havebeen reported.

Titration of the CD30 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 294-321 from the human protein was used as the immunogen for this CD30 antibody.

Aliquot the CD30 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.