The protein encoded by this gene is the CD3-epsilonpolypeptide, which together with CD3-gamma, -delta and -zeta, andthe T-cell receptor alpha/beta and gamma/delta heterodimers, formsthe T-cell receptor-CD3 complex. This complex plays an importantrole in coupling antigen recognition to several intracellularsignal-transduction pathways. The genes encoding the epsilon, gammaand delta polypeptides are located in the same cluster onchromosome 11. The epsilon polypeptide plays an essential role inT-cell development. Defects in this gene cause immunodeficiency.This gene has also been linked to a susceptibility to type Idiabetes in women.
Titration of the CD3e antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 154-182 from the human protein was used as the immunogen for this CD3e antibody.
Aliquot the CD3e antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
