This antibody reacts with the Ig domain of CD47 protein. It has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47, originally named integrin-associated protein (IAP), is an ~ 50kDa glycoprotein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus.CD47 may play a role in membrane transport and/or integrin dependent signal transduction.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Intact CD47 purified from placenta was used as the immunogen for this antibody.

Store the CD47 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigenic Surface Determinant Protein OA3; IAP; IAP antibody, Integrin Associated Protein; Integrin Associated Signal Transducer; MER6; OA3; Protein MER6; Rh Related Antigen, CD47 antibody