Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. [UniProt]

The stated application concentrations are suggested starting points. Titration of the CD59 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 74-110 from human CD59 was used as the immunogen for the CD59 antibody.

Aliquot the CD59 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.