CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Optimal dilution of the CD6 antibody should be determined by the researcher.

A CD8+ cytotoxic T-cell clone was used as the immunogen for the CD6 antibody.

Store the CD6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).