Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro (By similarity).
Titration of the Cdk9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 251-278 from the mouse protein was used as the immunogen for this Cdk9 antibody.
Aliquot the Cdk9 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
