This gene lies adjacent to the tumor suppressor geneCDKN2A in a region that is frequently mutated and deleted in a widevariety of tumors. This gene encodes a cyclin-dependent kinaseinhibitor, which forms a complex with CDK4 or CDK6, and preventsthe activation of the CDK kinases, thus the encoded proteinfunctions as a cell growth regulator that controls cell cycle G1progression. The expression of this gene was found to bedramatically induced by TGF beta, which suggested its role in theTGF beta induced growth inhibition. Two alternatively splicedtranscript variants of this gene, which encode distinct proteins,have been reported.

Titration of the CDKN2B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 102-130 from the human protein was used as the immunogen for this CDKN2B antibody.

Aliquot the CDKN2B antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.