Cystic fibrosis transmembrane conductance regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain.It is structurally similar to multidrug resistance (MDR1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates.The protein is a small conductance adenosine 3",5"-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts.CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the CFTR antibody to be titered up or down for optimal performance.

Human recombinant protein from the C-terminal region (within amino acids 1350-1480) was used as the immunogen for this CFTR antibody.

Store the CFTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).