BIRC3 is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.

Titration of the cIAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 101-131 from the human protein was used as the immunogen for this cIAP2 antibody.

Aliquot the cIAP2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.